MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulate pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) also reduces apoptosis in both INS-1E and αTC-1 cells. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance by activating AMPK.
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MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulate pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) also reduces apoptosis in both INS-1E and αTC-1 cells. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance by activating AMPK.
